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Open Access Prednisolone concentration in the cochlea of patients with perilymph fistula

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After iv administration of 200 mg prednisolone in patients with perilymph fistula, concentrations of the drug in the cochlea were determined. A specially adapted LC method was used for analysis. Mean concentrations of prednisolone in the perilymphe reached 95 ng/ml after 15–25 min, and 338 ng/ml after 30–45 min. The values reached 8 and 41% of the corresponding serum concentrations, respectively.

Document Type: Short Communication


Affiliations: 1: Institut für klinische Pharmakologie, Med. Fakultät, TU-Dresden, Fiedlerstr. 27, Dresden, 01307, Germany, Email: 2: Institut für klinische Pharmakologie, Med. Fakultät, TU-Dresden, Dresden, Germany 3: HNO-Klinik, Städtisches Klinikum, Dresden-Friedrichstadt, Germany

Publication date: March 1, 2007

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  • Pharmazie is one of the world's leading pharmaceutical journals. As a peer-reviewed scientific journal, DiePharmazie is regularly indexed in Current Contents/Life Sciences, Excerpta Medica, Analytical Abstracts, International Pharmaceutical Abstracts, Beilstein Current Facts in Chemistry, Chemical Engineering and Biotechnology Abstracts (CEABA) and Science Citation Index.
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