Skip to main content

Open Access Prednisolone concentration in the cochlea of patients with perilymph fistula

Download Article:
 Download
(PDF 62.2 kb)
 

Abstract:

After iv administration of 200 mg prednisolone in patients with perilymph fistula, concentrations of the drug in the cochlea were determined. A specially adapted LC method was used for analysis. Mean concentrations of prednisolone in the perilymphe reached 95 ng/ml after 15–25 min, and 338 ng/ml after 30–45 min. The values reached 8 and 41% of the corresponding serum concentrations, respectively.

Document Type: Short Communication

DOI: http://dx.doi.org/10.1691/ph.2007.3.6718

Affiliations: 1: Institut für klinische Pharmakologie, Med. Fakultät, TU-Dresden, Fiedlerstr. 27, Dresden, 01307, Germany, Email: reinhard.oertel@tu-dresden.de 2: Institut für klinische Pharmakologie, Med. Fakultät, TU-Dresden, Dresden, Germany 3: HNO-Klinik, Städtisches Klinikum, Dresden-Friedrichstadt, Germany

Publication date: March 1, 2007

More about this publication?
  • Pharmazie is one of the world's leading pharmaceutical journals. As a peer-reviewed scientific journal, DiePharmazie is regularly indexed in Current Contents/Life Sciences, Excerpta Medica, Analytical Abstracts, International Pharmaceutical Abstracts, Beilstein Current Facts in Chemistry, Chemical Engineering and Biotechnology Abstracts (CEABA) and Science Citation Index.
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
govi/pharmaz/2007/00000062/00000003/art00016
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more