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Open Access Prednisolone concentration in the cochlea of patients with perilymph fistula

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After iv administration of 200 mg prednisolone in patients with perilymph fistula, concentrations of the drug in the cochlea were determined. A specially adapted LC method was used for analysis. Mean concentrations of prednisolone in the perilymphe reached 95 ng/ml after 15–25 min, and 338 ng/ml after 30–45 min. The values reached 8 and 41% of the corresponding serum concentrations, respectively.
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Document Type: Short Communication

Affiliations: 1: Institut für klinische Pharmakologie, Med. Fakultät, TU-Dresden, Fiedlerstr. 27, Dresden, 01307, Germany, Email: reinhard.oertel@tu-dresden.de 2: Institut für klinische Pharmakologie, Med. Fakultät, TU-Dresden, Dresden, Germany 3: HNO-Klinik, Städtisches Klinikum, Dresden-Friedrichstadt, Germany

Publication date: 2007-03-01

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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