Prednisolone concentration in the cochlea of patients with perilymph fistula
Abstract:After iv administration of 200 mg prednisolone in patients with perilymph fistula, concentrations of the drug in the cochlea were determined. A specially adapted LC method was used for analysis. Mean concentrations of prednisolone in the perilymphe reached 95 ng/ml after 15–25 min, and 338 ng/ml after 30–45 min. The values reached 8 and 41% of the corresponding serum concentrations, respectively.
Document Type: Short Communication
Affiliations: 1: Institut für klinische Pharmakologie, Med. Fakultät, TU-Dresden, Fiedlerstr. 27, Dresden, 01307, Germany, Email: firstname.lastname@example.org 2: Institut für klinische Pharmakologie, Med. Fakultät, TU-Dresden, Dresden, Germany 3: HNO-Klinik, Städtisches Klinikum, Dresden-Friedrichstadt, Germany
Publication date: March 1, 2007
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