Open Access Prolonged cytotoxic effect of aqueous extracts from dried Viscum album on bladder cancer cells

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Abstract:

Aqueous extracts from whole dried mistletoe (Viscum album L., Iscucin®) are often used in anti-cancer treatment. We studied the effect of extracts obtained from mistletoe bushes that grew on different host trees on bladder cancer cells by means of MTT-colorimetric cell proliferation/survival assays. The extracts possessed concentration-dependent cytotoxic properties whose extent varied with the host tree, but did not always correlate with the corresponding mistletoe lectin content. A 2-hours treatment of bladder cancer cells triggered a later, strong cytotoxic effect. This prolonged effect suggests that instillation with Iscucin® has therapeutic potential for bladder cancer patients.

Document Type: Short Communication

DOI: http://dx.doi.org/10.1691/ph.2007.3.6765

Affiliations: 1: Laboratory of Cell Biology, Department of Biotechnology, University of Applied Sciences, Wädenswil, Switzerland 2: Laboratory of Cell Biology, Department of Biotechnology, University of Applied Sciences, Strasse, Wädenswil, Postleitzahl, Switzerland 3: Laboratory of Cell Biology, Department of Biotechnology, University of Applied Sciences, Strasse, Wädenswil, Postleitzahl, Switzerland, 4: Research Department, Paracelsus Hospital, Richterswil, Switzerland 5: Research Department, Paracelsus Hospital, Bergstrasse 16, Richterswil, CH-8805, Switzerland, Email: simoes@paracelsus-spital.ch

Publication date: March 1, 2007

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  • Pharmazie is one of the world's leading pharmaceutical journals. As a peer-reviewed scientific journal, DiePharmazie is regularly indexed in Current Contents/Life Sciences, Excerpta Medica, Analytical Abstracts, International Pharmaceutical Abstracts, Beilstein Current Facts in Chemistry, Chemical Engineering and Biotechnology Abstracts (CEABA) and Science Citation Index.
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