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Open Access Influence of ethanol water-content on gatifloxacin recrystallisations

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Abstract:

Gatifloxacin is a flouroquinolone anti-bacterial agent. This study proved that even the presence of small amounts of water in the recrystallisation medium influenced the product obtained. Different crystal forms were produced from various binary mixtures of ethanol and water. Where mixtures had a water content greater than (or equal to) 50% v/v, only hydrated crystal forms were produced and no ethanol was incorporated into the lattice.

Document Type: Short Communication

DOI: http://dx.doi.org/10.1691/ph.2007.3.6230

Affiliations: 1: Research Institute for Industrial Pharmacy, School of Pharmacy, North-West University, Potchefstroom Campus, Potchefstroom, South Africa 2: Research Institute for Industrial Pharmacy, School of Pharmacy, North-West University, Potchefstroom Campus, Potchefstroom, 2520, South Africa, Email: iifwl@puk.ac.za

Publication date: March 1, 2007

More about this publication?
  • Pharmazie is one of the world's leading pharmaceutical journals. As a peer-reviewed scientific journal, DiePharmazie is regularly indexed in Current Contents/Life Sciences, Excerpta Medica, Analytical Abstracts, International Pharmaceutical Abstracts, Beilstein Current Facts in Chemistry, Chemical Engineering and Biotechnology Abstracts (CEABA) and Science Citation Index.
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