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Open Access Influence of ethanol water-content on gatifloxacin recrystallisations

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Gatifloxacin is a flouroquinolone anti-bacterial agent. This study proved that even the presence of small amounts of water in the recrystallisation medium influenced the product obtained. Different crystal forms were produced from various binary mixtures of ethanol and water. Where mixtures had a water content greater than (or equal to) 50% v/v, only hydrated crystal forms were produced and no ethanol was incorporated into the lattice.
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Document Type: Short Communication

Affiliations: 1: Research Institute for Industrial Pharmacy, School of Pharmacy, North-West University, Potchefstroom Campus, Potchefstroom, South Africa 2: Research Institute for Industrial Pharmacy, School of Pharmacy, North-West University, Potchefstroom Campus, Potchefstroom, 2520, South Africa, Email: [email protected]

Publication date: 2007-03-01

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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