Flavan-3-ols and procyanidins from the bark of Salix purpurea L.
From a commercial aqueous ethanolic extract obtained from the bark of Salix purpurea L. the flavan-3-ols catechin, epicatechin, gallocatechin, catechin-3-O-(1-hydroxy-6-oxo-2-cyclohexene-1-carboxylic acid)-ester, the dimeric procyanidins B1, B3 and the trimeric procyanidins
epicatechin-(4β→8)-catechin-(4α→8)-catechin and epicatechin-(4β→8)-epicatechin-(4β→8)-catechin were isolated. Structure elucidation was performed by NMR, CD, MS, degradation and optical rotation methods. A fraction containing higher oligomeric procyanidins
was investigated by 13C NMR. Data indicate an average degree of oligomerization of 4 to 5 flavan-3-ol units with dihydroxylated B-rings and predominance of 2,3-cis-stereochemistry.
Document Type: Research Article
Affiliations: 1: Institute of Pharmaceutical Biology and Phytochemistry, Westfälische Wilhems-University, Münster, Germany 2: Institute of Pharmaceutical Biology and Phytochemistry, Westfälische Wilhems-University, Hittorfstr. 56, Münster, D-48149, Germany, Email: [email protected]
Publication date: 01 March 2007
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