Evaluation of preservative systems in opthalmic suspension of polymyxin B and dexamethasone by linear regression
An ophthalmic suspension of polymyxin B and dexametasone with 13 different preservative systems was evaluated by a linear regression method for rapid screening, using D-values. The products were challenged against Pseudomonas aeruginosa, Burkholderia cepacia, Staphylococcus
aureus, Candida albicans and Aspergillus niger. Since linear regression showed correlation coefficients higher than 0.84 the decimal reduction time (D-value) was then calculated. The comparison of D-values obtained for each microorganism and each product led to the selection
of the formula 9 = 10, which was selected to be submitted to the efficacy of antimicrobial preservation according to the European Pharmacopoeia.
Document Type: Research Article
Affiliations: 1: Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brasil 2: Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Avenida Professor Lineu Prestes, 580, São Paulo, 05508-900, Brasil, Email: [email protected]
Publication date: 01 March 2007
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