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Open Access A simple HPLC-UV method for the determination of dimenhydrinate and related substances – identification of an unknown impurity

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During the revision of the dimenhydrinate monograph of the European Pharmacopoeia a HPLC-UV method was developed. The procedure described allows a qualitative and quantitative determination of both dimenhydrinate compounds and of thirteen related substances. Furthermore a hitherto unknown impurity was identified and integrated into the purity check. Also 18 samples of dimenhydrinate have been tested. Thereby the relevant impurities of dimenhydrinate could be nominated and quantified.
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Document Type: Research Article

Affiliations: 1: Institute for Pharmacy, Pharmaceutical Chemistry, University of Leipzig, Brüderstraße 34, Leipzig, 04103, Germany, 2: Institute for Pharmacy, Pharmaceutical Chemistry, University of Leipzig, Leipzig, Germany

Publication date: 2007-03-01

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