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Open Access A simple HPLC-UV method for the determination of dimenhydrinate and related substances – identification of an unknown impurity

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During the revision of the dimenhydrinate monograph of the European Pharmacopoeia a HPLC-UV method was developed. The procedure described allows a qualitative and quantitative determination of both dimenhydrinate compounds and of thirteen related substances. Furthermore a hitherto unknown impurity was identified and integrated into the purity check. Also 18 samples of dimenhydrinate have been tested. Thereby the relevant impurities of dimenhydrinate could be nominated and quantified.
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Document Type: Research Article

Affiliations: 1: Institute for Pharmacy, Pharmaceutical Chemistry, University of Leipzig, Brüderstraße 34, Leipzig, 04103, Germany, 2: Institute for Pharmacy, Pharmaceutical Chemistry, University of Leipzig, Leipzig, Germany

Publication date: 2007-03-01

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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