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Open Access A simple HPLC-UV method for the determination of dimenhydrinate and related substances – identification of an unknown impurity

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During the revision of the dimenhydrinate monograph of the European Pharmacopoeia a HPLC-UV method was developed. The procedure described allows a qualitative and quantitative determination of both dimenhydrinate compounds and of thirteen related substances. Furthermore a hitherto unknown impurity was identified and integrated into the purity check. Also 18 samples of dimenhydrinate have been tested. Thereby the relevant impurities of dimenhydrinate could be nominated and quantified.

Document Type: Research Article


Affiliations: 1: Institute for Pharmacy, Pharmaceutical Chemistry, University of Leipzig, Brüderstraße 34, Leipzig, 04103, Germany, 2: Institute for Pharmacy, Pharmaceutical Chemistry, University of Leipzig, Leipzig, Germany

Publication date: March 1, 2007

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  • Pharmazie is one of the world's leading pharmaceutical journals. As a peer-reviewed scientific journal, DiePharmazie is regularly indexed in Current Contents/Life Sciences, Excerpta Medica, Analytical Abstracts, International Pharmaceutical Abstracts, Beilstein Current Facts in Chemistry, Chemical Engineering and Biotechnology Abstracts (CEABA) and Science Citation Index.
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