Open Access

The hypolipidemic effect of a new ACAT inhibitor, VULM 1457, in diabetic-hypercholesterolaemic rats

Authors: Adameová, A.1; Kuželová, M.2; Faberová, V.3; Švec, P.2

Source: Die Pharmazie - An International Journal of Pharmaceutical Sciences, Volume 60, Number 9, 1 September 2005 , pp. 714-715(2)

Publisher: Govi-Verlag

Buy & download fulltext article:

Open Access The full text is Open Access.

View now:
PDF 56.4kb 

Abstract:

The use of inhibitors of enzyme acyl-CoA: cholesterol acyltransferase (ACAT) seems to be a novel potential approach for a therapeutic treatment of dyslipidaemias and atherosclerosis. VULM 1457 is an ACAT inhibitor, which has expressed potent hypolipidemic and antiatherosclerotic effects in previous studies. In this study, we used streptozocin-induced diabetic rats, which were fed a fat-cholesterol diet to evaluate the affect of VULM 1457 on the atherogenic lipids levels in both plasma and liver. VULM 1457, with a slight influence on triglyceride levels, significantly reduced plasma and hepatic cholesterol concentrations (p < 0.05, p < 0.001; respectively) in the diabetic-hypercholesterolaemic rats.

Document Type: Short Communication

Affiliations: 1: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Kalinčiakova 8, Bratislava, 832 32, Slovak Republic, Email: adameova@fpharm.uniba.sk 2: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic 3: Department of Pharmacology, Drug Research Institute INC., Modra, Slovak Republic

Publication date: September 1, 2005

More about this publication?
  • Pharmazie is one of the world's leading pharmaceutical journals. As a peer-reviewed scientific journal, DiePharmazie is regularly indexed in Current Contents/Life Sciences, Excerpta Medica, Analytical Abstracts, International Pharmaceutical Abstracts, Beilstein Current Facts in Chemistry, Chemical Engineering and Biotechnology Abstracts (CEABA) and Science Citation Index.
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Terms & Conditions
  • ingentaconnect is not responsible for the content or availability of external websites
Related content

Tools

Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content

Text size:

A | A | A | A
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages. print icon Print this page