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The hypolipidemic effect of a new ACAT inhibitor, VULM 1457, in diabetic-hypercholesterolaemic rats

Authors: Adameová, A.1; Kuželová, M.2; Faberová, V.3; Švec, P.2

Source: Die Pharmazie - An International Journal of Pharmaceutical Sciences, Volume 60, Number 9, 1 September 2005 , pp. 714-715(2)

Publisher: Govi-Verlag

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The use of inhibitors of enzyme acyl-CoA: cholesterol acyltransferase (ACAT) seems to be a novel potential approach for a therapeutic treatment of dyslipidaemias and atherosclerosis. VULM 1457 is an ACAT inhibitor, which has expressed potent hypolipidemic and antiatherosclerotic effects in previous studies. In this study, we used streptozocin-induced diabetic rats, which were fed a fat-cholesterol diet to evaluate the affect of VULM 1457 on the atherogenic lipids levels in both plasma and liver. VULM 1457, with a slight influence on triglyceride levels, significantly reduced plasma and hepatic cholesterol concentrations (p < 0.05, p < 0.001; respectively) in the diabetic-hypercholesterolaemic rats.

Document Type: Short Communication

Affiliations: 1: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Kalinčiakova 8, Bratislava, 832 32, Slovak Republic, Email: 2: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic 3: Department of Pharmacology, Drug Research Institute INC., Modra, Slovak Republic

Publication date: September 1, 2005

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  • Pharmazie is one of the world's leading pharmaceutical journals. As a peer-reviewed scientific journal, DiePharmazie is regularly indexed in Current Contents/Life Sciences, Excerpta Medica, Analytical Abstracts, International Pharmaceutical Abstracts, Beilstein Current Facts in Chemistry, Chemical Engineering and Biotechnology Abstracts (CEABA) and Science Citation Index.
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