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Open Access Three new pimaren diterpenoids from marine mangrove plant, Bruguiera gymnorrhiza

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Abstract:

Three new pimaren diterpenoids, ent-8(14)-pimarene-15R,16-diol (1), ent-8(14)-pimarene-1α,15R,16-triol (2), and (5R, 9S, 10R, 13S, 15S)-ent-8(14)-pimarene-1-oxo-15R,16-diol (3), along with three known diterpenoids (4–6) have been isolated from the stem of mangrove plant Bruguiera gymnorrhiza. The structures of compounds 1–3 were determined by extensive spectroscopic (2D NMR, MS, IR, and CD) analysis, and 3 and 5 showed moderate cytotoxic activities against L-929 and K562, respectively.

Document Type: Research Article

Affiliations: 1: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, P.R. China 2: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100083, P.R. China, Email: whlin@bjmu.edu.cn

Publication date: 2005-09-01

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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