Open Access Isoquinolone and protoberberine alkaloids from Stephania rotunda

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Chemical investigation of Stephania rotunda Lour. growing in Viet Nam led to the isolation and structural elucidation of three new alkaloids, 5-hydroxy-6,7-dimethoxy-3,4-dihydroisoquinolin-1(2H)-one (1), thaicanine 4-O-β-L-glucoside (6), as well as (–)-thaicanine N-oxide (4-hydroxycorynoxidine) (8), along with 23 known alkaloids. These structures were determined on the basis of MS and NMR spectroscopic data.

Document Type: Research Article

Affiliations: 1: Institute of Chemistry, Vietnamese Academy of Science and Technology, Hanoi, Viet Nam 2: Department of Bioorganic Chemistry, Leibniz-Institute of Plant Biochemistry, Halle/Saale, Germany 3: Institute of Chemistry, Vietnamese Academy of Science and Technology, 18-Hoang Quoc Viet Road, Hanoi, Viet Nam, Email:

Publication date: September 1, 2005

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  • Pharmazie is one of the world's leading pharmaceutical journals. As a peer-reviewed scientific journal, DiePharmazie is regularly indexed in Current Contents/Life Sciences, Excerpta Medica, Analytical Abstracts, International Pharmaceutical Abstracts, Beilstein Current Facts in Chemistry, Chemical Engineering and Biotechnology Abstracts (CEABA) and Science Citation Index.
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