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Open Access 2-(Aminoacylamino)benzophenones: farnesyltransferase inhibition and antimalarial activity

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Abstract:

The use of amino acids as acyl substitutents at the 2-amino group of our benzophenone core structure yielded compounds with mainly good to moderate farnesyltransferase inhibitory and moderate antimalarial activity. However, these farnesyltransferase inhibitors display some degree of selectivity towards malarial parasites since there was no cytotoxic activity observed at 70–80 μM.

Document Type: Research Article

Affiliations: 1: Department für Pharmazie – Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, München, Germany 2: Biochemisches Institut der Justus-Liebig-Universität Gießen, Gießen, Germany 3: Hans-Knöll-Institut für Naturstoff-Forschung e.V., Jena, Germany 4: Department für Pharmazie – Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, Butenandtstraße 5–13, München, D-81377, Germany, Email: Martin.Schlitzer@cup.uni-muenchen.de

Publication date: 2005-09-01

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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