Open Access 2-(Aminoacylamino)benzophenones: farnesyltransferase inhibition and antimalarial activity

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Abstract:

The use of amino acids as acyl substitutents at the 2-amino group of our benzophenone core structure yielded compounds with mainly good to moderate farnesyltransferase inhibitory and moderate antimalarial activity. However, these farnesyltransferase inhibitors display some degree of selectivity towards malarial parasites since there was no cytotoxic activity observed at 70–80 μM.

Document Type: Research Article

Affiliations: 1: Department für Pharmazie – Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, München, Germany 2: Biochemisches Institut der Justus-Liebig-Universität Gießen, Gießen, Germany 3: Hans-Knöll-Institut für Naturstoff-Forschung e.V., Jena, Germany 4: Department für Pharmazie – Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, Butenandtstraße 5–13, München, D-81377, Germany, Email: Martin.Schlitzer@cup.uni-muenchen.de

Publication date: September 1, 2005

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  • Pharmazie is one of the world's leading pharmaceutical journals. As a peer-reviewed scientific journal, DiePharmazie is regularly indexed in Current Contents/Life Sciences, Excerpta Medica, Analytical Abstracts, International Pharmaceutical Abstracts, Beilstein Current Facts in Chemistry, Chemical Engineering and Biotechnology Abstracts (CEABA) and Science Citation Index.
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