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Open Access Modeling the electrophoretic mobility of analytes in binary solvent electrolyte systems in capillary electrophoresis using an artificial neural network

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An artificial neural network (ANN) methodology was used to model the electrophoretic mobility of basic analytes in binary solvent electrolyte systems. The electrophoretic mobilities in pure solvent electrolytes, and the volume fractions of the solvents in mixtures were used as input. The electrophoretic mobilities in mixed solvent buffers were employed as the output of the network. The optimized topology of the network was 3-3-1. 32 experimental mobility data sets collected from the literature were employed to test the correlation ability and prediction capability of the proposed method. The mean percentage deviation (MPD) between the experimental and calculated values was used as an accuracy criterion. The MPDs obtained for different numerical analyses varied between 0.21% and 13.74%. The results were also compared with similar calculated mobilities which were derived from the best multiple linear model from the literature. From these results it was found that the ANN methodology is superior to the multiple linear model.
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Document Type: Research Article

Affiliations: 1: School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, 51664, Iran, Email: [email protected] 2: Kimia Research Institute, University of Tabriz, Tabriz, Iran 3: Department of Analytical Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran 4: GlaxoSmithKline, Pharmaceutical Development, Strasse, Harlow, Essex, UK 5: Institute of Pharmaceutical Innovation, School of Life Sciences, University of Bradford, Bradford, UK

Publication date: 01 September 2005

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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