Anhydrous formic acid and acetic anhydride as solvent or additive in nonaqueous titrations
The use and importance of formic acid and acetic anhydride (Ac2O) is increasing in nonaqueous acid-base titrations, but their interaction with the solutes is poorly understood. This paper attempts to clarify the effect of the solvents; NMR and spectrophotometric investigations
were done to reveal the interactions between some bases and the mentioned solvents. Anhydrous formic acid is a typical protogenic solvent but both the relative permittivity and acidity are higher than those of acetic acid (mostly used in assays of bases). These differences originate from the
different chemical structures: liquid acetic acid contains basically cyclic dimers while formic acid forms linear associates. Ac2O is obviously not an acidic but an aprotic (very slightly protophilic) solvent, which supposedly dissociates slightly into acetyl (CH3CO+)
and acetate (AcO–) ions. In fact, some bases react with Ac2O forming an associate: the Ac+ group is bound to the δ– charged atom of the reactant while AcO– is associated with the δ+ group
at appropriate distance.
No References for this article.
No Supplementary Data.
Document Type: Research Article
Department of Inorganic and Analytical Chemistry, Eötvös University, P.O. Box 32, Budapest, H-1518, Hungary, Email: email@example.com
Department of Inorganic and Analytical Chemistry, Debrecen University, Debrecen, Hungary
Department of Inorganic and Analytical Chemistry, Eötvös University, Budapest, Hungary
Publication date: 2005-09-01
More about this publication?
Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
- Information for Authors
- Submit a Paper
- Subscribe to this Title
- Ingenta Connect is not responsible for the content or availability of external websites