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Open Access Trypanocidal activity of bergenin, the major constituent of Flueggea virosa, on Trypanosoma brucei

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The presence of bergenin in substantial amounts in the methanol leaves extract of Flueggea virosa (Euphorbiaceae) was established as a strong chemotaxomic point of differentiation between Flueggea virosa and Securinega virosa. Bergenin showed an inhibitory effect on the growth of the bloodstream form of Trypanosoma brucei with an IC50 value of 1 μM.
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Document Type: Short Communication

Affiliations: 1: Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Box 812, Yaoundé, Cameroon, Email: bnyasse@uycdc.uninet.cm 2: Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon 3: Department of Biology, Higher Teachers' Training College, University of Yaoundé I, Yaoundé, Cameroon 4: Laboratoire de Synthèse et Physicochimie de molécules d'Intérêt Biologique, Université Paul Sabatier, Toulouse, France 5: LEDSS, Université Joseph Fourier, Grenoble, France

Publication date: 2004-06-01

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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