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Trypanocidal activity of bergenin, the major constituent of Flueggea virosa, on Trypanosoma brucei

Authors: Nyasse, B.1; Nono, J.2; Sonke, B.3; Denier, C.4; Fontaine, C.5

Source: Die Pharmazie - An International Journal of Pharmaceutical Sciences, Volume 59, Number 6, 1 June 2004 , pp. 492-494(3)

Publisher: Govi-Verlag

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Abstract:

The presence of bergenin in substantial amounts in the methanol leaves extract of Flueggea virosa (Euphorbiaceae) was established as a strong chemotaxomic point of differentiation between Flueggea virosa and Securinega virosa. Bergenin showed an inhibitory effect on the growth of the bloodstream form of Trypanosoma brucei with an IC50 value of 1 μM.

Document Type: Short Communication

Affiliations: 1: Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Box 812, Yaoundé, Cameroon, Email: bnyasse@uycdc.uninet.cm 2: Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon 3: Department of Biology, Higher Teachers' Training College, University of Yaoundé I, Yaoundé, Cameroon 4: Laboratoire de Synthèse et Physicochimie de molécules d'Intérêt Biologique, Université Paul Sabatier, Toulouse, France 5: LEDSS, Université Joseph Fourier, Grenoble, France

Publication date: June 1, 2004

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  • Pharmazie is one of the world's leading pharmaceutical journals. As a peer-reviewed scientific journal, DiePharmazie is regularly indexed in Current Contents/Life Sciences, Excerpta Medica, Analytical Abstracts, International Pharmaceutical Abstracts, Beilstein Current Facts in Chemistry, Chemical Engineering and Biotechnology Abstracts (CEABA) and Science Citation Index.
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