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Dehydroepiandrosterone sulfate increases hepatic ubiquinone-9 in male F-344 rats

Author: Khan, S. A.

Source: Die Pharmazie - An International Journal of Pharmaceutical Sciences, Volume 59, Number 6, 1 June 2004 , pp. 491-492(2)

Publisher: Govi-Verlag

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Abstract:

Administration of dehydroepiandrosterone sulfate (DHEAS) for 14 days caused a significant increase in the total ubiquinone-9 level in the hepatic tissue of male F-344 rats (p < 0.05). Hepatic ubiquinone-10 level of DHEAS-treated rats however, was found not to be statistically different from control animals. These findings suggest that peroxisome proliferator DHEAS displays typical hepatic response in increasing ubiquinone concentration in the rat.

Document Type: Short Communication

Affiliations: Department of Pharmacology and Toxicology, Brody School of Medicine, East Pharmacol-Carolina University, NC, Strasse, Greenville, PA 16802, USA, Email: sak13@psu.edu

Publication date: June 1, 2004

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  • Pharmazie is one of the world's leading pharmaceutical journals. As a peer-reviewed scientific journal, DiePharmazie is regularly indexed in Current Contents/Life Sciences, Excerpta Medica, Analytical Abstracts, International Pharmaceutical Abstracts, Beilstein Current Facts in Chemistry, Chemical Engineering and Biotechnology Abstracts (CEABA) and Science Citation Index.
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