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Open Access Effect of exogenous leptin administration on high fat diet induced oxidative stress

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Abstract:

The objective of the present study was to explore the tissue lipid peroxidation and antioxidant status in mice receiving exogenous leptin along with high fat diet for a period of 6 weeks. Significantly elevated levels of tissue thiobarbituric acid reactive substances (TBARS), conjugated dienes (CD) and significantly lowered levels of glutathione and its related enzymes were observed in the liver, heart and kidney of mice fed with a high fat diet as compared with the control mice fed with a standard pellet diet. Subsequent to the treatment with high fat diet (ie., after the initial period of 30 days) exogenous leptin (230 μg kg–1 body weight) was simultaneously administered along with the regular high fat diet every alternate day for 15 days. Leptin administration significantly lowered the tissue levels of TBARS, CD and elevated the activities of reduced glutathione (GSH), glutathione peroxidase (GPX) and glutathione S-transferase (GST) in both the control and high fat diet fed mice. Thus leptin supplementation was found to be effective in attenuating high fat diet induced oxidative stress.

Document Type: Research Article

Affiliations: 1: Department of Biochemistry, Annamalai University, Annamalainagar, Tamilnadu, India 2: Department of Biochemistry, Annamalai University, Annamalainagar, Tamilnadu, 608 002, India, Email: nalininam@yahoo.com

Publication date: June 1, 2004

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  • Pharmazie is one of the world's leading pharmaceutical journals. As a peer-reviewed scientific journal, DiePharmazie is regularly indexed in Current Contents/Life Sciences, Excerpta Medica, Analytical Abstracts, International Pharmaceutical Abstracts, Beilstein Current Facts in Chemistry, Chemical Engineering and Biotechnology Abstracts (CEABA) and Science Citation Index.
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