Topische Verfügbarkeit von Hydrocortisonacetat aus handelsüblichen halbfesten Formulierungen
Liberation of hydrocortisone acetate from different commercial formulations
In this article the release of hydrocortisone acetate (HC-acetate) from three commercial semisolid formulations (Ebenol®-ointment, Soventol® HC cream and Fenistil® hydrocortisone ointment) was measured by means of a multilayer membrane system (MLMS) described in the literature. The formulations are different regarding rate and extent of the release of HC-acetate. The release of HC-acetate form the Soventol® HC cream is very fast and results in high topical availability. In contrast, HC-acetate shows a sustained release from the Fenistil® hydrocortisone ointment. The release of HC-acetate from the Ebenol®-ointment is between that of the Soventol® HC cream and that of the Fenistil®-ointment. In summary, HC-acetate shows a shorter mean liberation time (MDT) and a higher topical availability from Soventol® HC cream in comparison to the other formulations studied.
Document Type: Research Article
Affiliations: 1: Fachbereich Pharmazie, Institut für Pharmazeutische Technologie und Biopharmazie der Martin-Luther-Universität Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, Halle/Saale, D-06120, Deutschland, Email: [email protected] 2: Fachbereich Pharmazie, Institut für Pharmazeutische Technologie und Biopharmazie der Martin-Luther-Universität, Halle-Wittenberg, Deutschland
Publication date: 2004-06-01
- Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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