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Open Access Photostability of epinephrine – the influence of bisulfite and degradation products

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Abstract:

Sulfites are previously demonstrated to increase the photodegradation of epinephrine. The aim of this study was to clarify the factors responsible for this effect. Adrenochrome sulfonate seems to be the important substance. Photoproduction of singlet oxygen is indicated to be the mechanism by which adrenochrome sulfonate acts. Protection of epinephrine solutions from irradiation <418 nm prevented the photodegradation. A reaction pathway for the photochemical decomposition of epinephrine in the presence of bisulfite is suggested.

Document Type: Research Article

Affiliations: 1: School of Pharmacy Department of Pharmaceutics, University of Oslo, P.O. Box 1068, Oslo, 0316, Norway, Email: Jorgeb@farmasi.uio.no 2: School of Pharmacy Department of Pharmaceutics, University of Oslo, Oslo, Norway

Publication date: June 1, 2004

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  • Pharmazie is one of the world's leading pharmaceutical journals. As a peer-reviewed scientific journal, DiePharmazie is regularly indexed in Current Contents/Life Sciences, Excerpta Medica, Analytical Abstracts, International Pharmaceutical Abstracts, Beilstein Current Facts in Chemistry, Chemical Engineering and Biotechnology Abstracts (CEABA) and Science Citation Index.
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