Skip to main content

Open Access Photostability of epinephrine – the influence of bisulfite and degradation products

Download Article:
(PDF 134.9 kb)


Sulfites are previously demonstrated to increase the photodegradation of epinephrine. The aim of this study was to clarify the factors responsible for this effect. Adrenochrome sulfonate seems to be the important substance. Photoproduction of singlet oxygen is indicated to be the mechanism by which adrenochrome sulfonate acts. Protection of epinephrine solutions from irradiation <418 nm prevented the photodegradation. A reaction pathway for the photochemical decomposition of epinephrine in the presence of bisulfite is suggested.

Document Type: Research Article

Affiliations: 1: School of Pharmacy Department of Pharmaceutics, University of Oslo, P.O. Box 1068, Oslo, 0316, Norway, Email: 2: School of Pharmacy Department of Pharmaceutics, University of Oslo, Oslo, Norway

Publication date: June 1, 2004

More about this publication?
  • Pharmazie is one of the world's leading pharmaceutical journals. As a peer-reviewed scientific journal, DiePharmazie is regularly indexed in Current Contents/Life Sciences, Excerpta Medica, Analytical Abstracts, International Pharmaceutical Abstracts, Beilstein Current Facts in Chemistry, Chemical Engineering and Biotechnology Abstracts (CEABA) and Science Citation Index.
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Partial Open Access Content
Partial Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more