Skip to main content

Open Access Synthesis of chloro and bromo substituted 5-(indan-1′-yl)tetrazoles and 5-(indan-1′-yl)methyltetrazoles as possible analgesic agents

Download Article:
(PDF 94.85546875 kb)
Chloro and bromo substututed indanyl tetrazoles (compounds 5a, b) and indanyl methyltetrazoles (compounds 5c, 5d) have been synthesized from their respective acids through amide and nitrile routes, and characterized. The title compounds (5a, 5b, 5c and 5d) were subjected for their analgesic activity in the acetic acid induced writhing test on albino mice. The significant (p < 0.001) analgesic activity, exhibited by the compound 5b at a dose of 50 mg/kg body weight, was comparable to that of phenylbutazone and indometacin at a dose of 100 and 50 mg/kg body weight respectively. The effect of substitution at the benzenoid part of the indan nucleus and chain lenght on analgesic activity was in the following order: bromine > chlorine and tetrazole > methyltetrazole.
No References for this article.
No Supplementary Data.
No Data/Media
No Metrics

Document Type: Research Article

Affiliations: 1: Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Strasse, Dhaka, Bangladesh, 1000, India, Email: [email protected] 2: Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Kolkata, India

Publication date: 2004-06-01

More about this publication?
  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more