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Open Access Study and analytical application of ion-pair formation in the system fluoxetine-pyrocatechol violet and fluvoxamine-pyrocatechol violet

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Pyrocatechol violet (PCV) reacts in aqueous media with fluoxetine (FLX) and fluvoxamine (FLV) forming coloured ion-association complexes, which are insoluble in water but quantitatively extracted into chloroform-n-butanol mixture. The composition of the compounds, studied by spectrophotometric methods showed that the molar ratio PCV : FLX and PCV : FLV is 1 : 1. The compounds were characterized by UV-VIS, IR and NMR spectrometry. Under optimal experimental conditions fluoxetine and fluvoxamine were determined in the range 1.3–18.0 μg/ml and 2.6–39.1 μg/ml, respectively. The proposed methods have been succesfully applied to the determination of these drugs in pharmaceuticals and natural samples.

Document Type: Research Article

Affiliations: 1: Institute of Chemistry, University of Białystok, Białystok, Poland 2: Institute of Chemistry, University of Białystok, ul. Hurtowa 1, Białystok, PL-15-399, Poland, Email: annaj@uwb.edu.pl

Publication date: April 1, 2003

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  • Pharmazie is one of the world's leading pharmaceutical journals. As a peer-reviewed scientific journal, DiePharmazie is regularly indexed in Current Contents/Life Sciences, Excerpta Medica, Analytical Abstracts, International Pharmaceutical Abstracts, Beilstein Current Facts in Chemistry, Chemical Engineering and Biotechnology Abstracts (CEABA) and Science Citation Index.
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