Allergy vaccines: dreams and reality

Author: Crameri, Reto

Source: Expert Review of Vaccines, 1 December 2007, vol. 6, no. 6, pp. 991-999(9)

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Abstract:

Allergy, extrinsic asthma and atopic eczema derive from deregulated immune responses against innocuous antigens. The incidence of atopic diseases is actually affecting approximately 30% of the population in industrialized countries. Although much progress has been achieved in the development of efficient symptomatic treatments for allergic diseases, the only curative treatment remains allergen-specific immunotherapy. In contrast to classical vaccines, which elicit strong host immune responses after one or a few injections, allergen-specific immunotherapy might require a long treatment time of 3–5¬†years with up to 80¬†injections to confer some protection. The reality is that ‘allergy vaccines’ achieve beneficial effects through immunomodulation, which takes a long time to establish. The dream would be to develop highly efficient allergy vaccines able to cure the disease with a few injections.

Keywords: IgE; allergy; immunotherapy; vaccination concepts; vaccines

Document Type: Research Article

DOI: http://dx.doi.org/10.1586/14760584.6.6.991

Publication date: December 1, 2007

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