Cancer vaccines and tumor dormancy: a long-term struggle between host antitumor immunity and persistent cancer cells?

Author: Quesnel, Bruno

Source: Expert Review of Vaccines, 1 December 2006, vol. 5, no. 6, pp. 773-781(9)

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Abstract:

Tumor dormancy is a phenomenon characterized by the persistence of residual cancer cells for long periods in the host. Evidence has emerged that a balance exists between the immune response and dormant tumor cells. This review presents our current understanding of the immune relationship between host and dormant tumor cells and the mechanism developed by these cells to escape host antitumor immunity. Implications of this immune escape for cancer vaccine strategy are considered.

Keywords: B7-H1; CXCL10; PD-L1; cytotoxic T cells; natural killer; stem cell; tumor dormancy

Document Type: Research Article

DOI: http://dx.doi.org/10.1586/14760584.5.6.773

Publication date: December 1, 2006

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