Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates

Authors: Haynes, Barton F; Montefiori, David C

Source: Expert Review of Vaccines, Volume 5, Number 4, August 2006 , pp. 579-595(17)

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Abstract:

Neutralizing antibody induction is a key feature of many effective vaccines and is the only immune response that has proven to be capable of completely blocking AIDS virus infection in animal models. Unfortunately, the extensive genetic variability and complex immune-evasion strategies of HIV-1 have thwarted all attempts to date at eliciting an effective neutralizing antibody response with candidate HIV-1 vaccine immunogens. Recent advances in our understanding of how these evasion strategies operate, coupled with growing progress in unravelling the structure and immunobiology of the viral envelope glycoproteins, are contributing to novel immunogen designs to overcome the many barriers to inducing protective antibodies against HIV-1.

Keywords: antiretroviral therapy; HIV-1; host cell fusion; immunogen; neutralizing antibody induction

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14760584.5.4.579

Publication date: 2006-08-01

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Expert Review of Vaccines provides expert reviews on the clinical effectiveness of new vaccines. Coverage includes vaccine technology, vaccine adjuvants, prophylactic vaccines, therapeutic vaccines, AIDS vaccines and vaccines in bioterrorism.
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