Achieving directed immunostimulating complexes incorporation

Authors: Wikman, Maria; Friedman, Mikaela; Pinitkiatisakul, Sunan; Andersson, Christin; Lövgren-Bengtsson, Karin; Lundén, Anna; Ståhl, Stefan

Source: Expert Review of Vaccines, Volume 5, Number 3, June 2006 , pp. 395-403(9)

Publisher: Expert Reviews

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Abstract:

In recent years, several studies have been reported with the common aim of generating general expression systems for straightforward production and subsequent coupling of expressed antigens to an adjuvant system. Here, we describe a series of such efforts with a common theme of using gene fusion technology for association of recombinant antigens to immunostimulating complexes (iscoms). In the early stages of vaccine development, uniform antigen preparations are crucial to allow the comparison of immune responses to different antigens, or even subdomains thereof, and we believe that the described systems constitute an important development in this context.

Keywords: adjuvant; affinity purification; fusion protein; iscom; subunit vaccine

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14760584.5.3.395

Publication date: 2006-06-01

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Expert Review of Vaccines provides expert reviews on the clinical effectiveness of new vaccines. Coverage includes vaccine technology, vaccine adjuvants, prophylactic vaccines, therapeutic vaccines, AIDS vaccines and vaccines in bioterrorism.
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