Achieving directed immunostimulating complexes incorporation
Authors: Wikman, Maria; Friedman, Mikaela; Pinitkiatisakul, Sunan; Andersson, Christin; Lövgren-Bengtsson, Karin; Lundén, Anna; Ståhl, Stefan
Source: Expert Review of Vaccines, 1 June 2006, vol. 5, no. 3, pp. 395-403(9)
Abstract:In recent years, several studies have been reported with the common aim of generating general expression systems for straightforward production and subsequent coupling of expressed antigens to an adjuvant system. Here, we describe a series of such efforts with a common theme of using gene fusion technology for association of recombinant antigens to immunostimulating complexes (iscoms). In the early stages of vaccine development, uniform antigen preparations are crucial to allow the comparison of immune responses to different antigens, or even subdomains thereof, and we believe that the described systems constitute an important development in this context.
Document Type: Research Article