Meningococcal serogroup W135 in the African meningitis belt: epidemiology, immunity and vaccines
Authors: Mueller, Judith E; Borrow, Raymond; Gessner, Bradford D
Source: Expert Review of Vaccines, 1 June 2006, vol. 5, no. 3, pp. 319-336(18)
Abstract:In the sub-Saharan African meningitis belt there is a region of hyperendemic and epidemic meningitis stretching from Senegal to Ethiopia. The public health approaches to meningitis epidemics, including those related to vaccine use, have assumed that Neisseria meningitidis serogroup A will cause the most disease. During 2001 and 2002, the first large-scale epidemics of serogroup W135 meningitis in sub-Saharan Africa were reported from Burkina Faso. The occurrence of N. meningitidis W135 epidemics has led to a host of new issues, including the need for improved laboratory diagnostics for identifying serogroups during epidemics, an affordable supply of serogroup W135-containing polysaccharide vaccine for epidemic control where needed, and re-evaluating the long-term strategy of developing a monovalent A conjugate vaccine for the region. This review summarizes the existing data on N. meningitidis W135 epidemiology, immunology and vaccines as they relate to meningitis in sub-Saharan Africa.
Document Type: Research Article
Publication date: 2006-06-01T00:00:00