Authors: Pichichero, Michael E; DeTora, Lisa M; Johnson, David R

Source: Expert Review of Vaccines, Volume 5, Number 2, April 2006 , pp. 175-187(13)

Publisher: Expert Reviews

Abstract:

Pertussis causes substantial morbidity among adolescents and adults, as well as other persons in contact with affected individuals. In the context of widespread childhood immunization, vaccination of adolescents and adults is a relatively new strategy for reducing the disease in all age groups. ADACEL^® is a tetanus–diphtheria–acellular pertussis combination vaccine (incorporating pertussis toxoid, filamentous hemagglutinin, pertactin and fimbriae type 2 and 3 antigens) formulated for use in adolescents and adults based on similar products designed for infants and children. ADACEL vaccine is approved for use in Australia, Canada, Germany and the USA, and has been demonstrated to induce robust immune responses and acceptable levels of reactogenicity in clinical trials. Surveillance data from Canada, where ADACEL vaccine has been used in adolescents and adults in conjunction with ongoing childhood vaccination for several years, indicate an enhanced overall reduction in pertussis disease.

Keywords: ADACEL®; Bordetella pertussis; combination vaccine; Tdap; vaccine; whooping cough

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14760584.5.2.175

Publication date: 2006-04-01

More about this publication?

• Expert Review of Vaccines provides expert reviews on the clinical effectiveness of new vaccines. Coverage includes vaccine technology, vaccine adjuvants, prophylactic vaccines, therapeutic vaccines, AIDS vaccines and vaccines in bioterrorism.
• Editorial Board
• Information for Authors
• Submit a Paper
• Subscribe to this Title
• Information for Advertisers
• Terms & Conditions
• Information for Librarians
• Free Trials
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Technology ,  Medicine ,  Medicine (General)
• By this author: Pichichero, Michael E ;  DeTora, Lisa M ;  Johnson, David R

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers