Poultry coccidiosis: recent advancements in control measures and vaccine development

Authors: Dalloul, Rami A; Lillehoj, Hyun S

Source: Expert Review of Vaccines, Volume 5, Number 1, February 2006 , pp. 143-163(21)

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Abstract:

Coccidiosis is recognized as the major parasitic disease of poultry and is caused by the apicomplexan protozoan Eimeria. Coccidiosis seriously impairs the growth and feed utilization of infected animals resulting in loss of productivity. Conventional disease control strategies rely heavily on chemoprophylaxis and, to a certain extent, live vaccines. Combined, these factors inflict tremendous economic losses to the world poultry industry in excess of US$3 billion annually. Increasing regulations and bans on the use of anticoccidial drugs coupled with the associated costs in developing new drugs and live vaccines increases the need for the development of novel approaches and alternative control strategies for coccidiosis. This paper aims to review the current progress in understanding the host immune response to Eimeria and discuss current and potential strategies being developed for coccidiosis control in poultry.

Keywords: anticoccidials; coccidiosis; Eimeria; embryo vaccination; immunomodulation; intestinal immunity; live vaccines; poultry; recombinant vaccines

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14760584.5.1.143

Publication date: 2006-02-01

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Expert Review of Vaccines provides expert reviews on the clinical effectiveness of new vaccines. Coverage includes vaccine technology, vaccine adjuvants, prophylactic vaccines, therapeutic vaccines, AIDS vaccines and vaccines in bioterrorism.
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