Delivering vaccines into the skin without needles and syringes

Author: Partidos, Charalambos D

Source: Expert Review of Vaccines, Volume 2, Number 6, December 2003 , pp. 753-761(9)

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Abstract:

The skin is a highly accessible organ and due to the presence of powerful antigen-presenting cells in the epidermis, it functions as an immune barrier. This makes the skin an attractive route for potential delivery of vaccines by painless and user-friendly methods without the requirement of needles and syringes. This article reviews current attempts to administer vaccines into the skin and discusses some of the scientific issues related to the emerging delivery technologies.

Keywords: adjuvants; skin immunization; vaccine delivery; vaccines

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14760584.2.6.753

Publication date: 2003-12-01

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Expert Review of Vaccines provides expert reviews on the clinical effectiveness of new vaccines. Coverage includes vaccine technology, vaccine adjuvants, prophylactic vaccines, therapeutic vaccines, AIDS vaccines and vaccines in bioterrorism.
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