Prevention of autoimmune diabetes by DNA vaccination

Author: Prud'homme, Gérald J

Source: Expert Review of Vaccines, Volume 2, Number 4, August 2003 , pp. 533-540(8)

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Abstract:

DNA vaccination with antigen expression plasmids has been introduced as a simple method of inducing immunity to the antigens of infectious agents or tumors. Although DNA vaccination is generally immunostimulatory, it is possible to design suppressive vaccines that protect against autoimmune diseases such as Type 1 diabetes. In mice prone to diabetes, investigators have delivered a plasmid encoding an islet-cell antigen such as insulin B chain, glutamic acid decarboxylase, or antigen/immunoglobulin G-Fc fusion constructs, with or without codelivery of another gene encoding a cytokine or other immunoregulatory molecule. This approach has led to protection against disease, related to the generation of regulatory Tcells and increased production of regulatory cytokines. DNA vaccination is a promising approach to autoimmune disease prevention.

Keywords: autoimmunity; CpG; cytokines; diabetes; DNA vaccination; gene therapy; glutamic acid decarboxylase; insulin

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14760584.2.4.533

Publication date: 2003-08-01

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Expert Review of Vaccines provides expert reviews on the clinical effectiveness of new vaccines. Coverage includes vaccine technology, vaccine adjuvants, prophylactic vaccines, therapeutic vaccines, AIDS vaccines and vaccines in bioterrorism.
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