Conditional live virus as a novel approach towards a safe live attenuated HIV vaccine
Authors: Das, Atze T; Zhou, Xue; Vink, Monique; Klaver, Bep; Berkhout, Ben
Source: Expert Review of Vaccines, 1 October 2002, vol. 1, no. 3, pp. 293-301(9)
Abstract:To control the worldwide spread of HIV, a safe and effective prophylactic vaccine is urgently needed. Studies with the simian immunodeficiency virus demonstrated that a live attenuated virus can be effective as a vaccine, but serious concerns about the safety of such a vaccine virus have arisen. We propose a conditional live virus, of which the replication can be switched on and off at will, as a novel approach for an HIV vaccine.
Document Type: Research Article
Publication date: October 1, 2002