Growth hormone replacement therapy in adults with growth hormone deficiency: benefits and cost-effectiveness

Authors: Tanriverdi, Fatih; Unluhizarci, Kursad; Kelestimur, Fahrettin

Source: Expert Review of Pharmacoeconomics and Outcomes Research, Volume 6, Number 2, April 2006 , pp. 131-138(8)

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Abstract:

In recent years, growth hormone deficiency in adults has been accepted as a clinical entity. Although beneficial effects of growth hormone replacement therapy (GHRT) in adults – including improvements in body composition, lipid profile, quality of life and bone mineral density – have been shown in many studies, there are still controversies and ongoing debates regarding GHRT in adults. It seems that this subject will continue to be a hot topic in the near future. Therefore, the aim of this review is to re-evaluate the current understanding on GHRT in adults in the light of recent data. Additionally, the clinical aspects, risks, benefits and cost–effectiveness of GHRT are summarized.

Keywords: cardiovascular risk factors; cost–effectiveness; growth hormone; growth hormone deficiency; growth hormone replacement therapy; lipid profile; osteoporosis; quality of life; recombinant human growth hormone

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14737167.6.2.131

Publication date: 2006-04-01

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Expert Review of Pharmacoeconomics & Outcomes Research provides expert commentary on cost-benefit and pharmacoeconomic issues relating to the clinical use of drugs and therapeutic approaches. Coverage includes pharmacoeconomics and quality-of-life research, therapeutic outcomes, evidence-based medicine and cost-benefit research.
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