Authors: Reed, Anna; Williams, Trevor; Snell, Gregory

Source: Expert Review of Pharmacoeconomics and Outcomes Research, Volume 3, Number 6, December 2003 , pp. 729-740(12)

Publisher: Expert Reviews

Abstract:

Chronic obstructive pulmonary disease is a major cause of morbidity and mortality throughout the world. Standard management includes avoidance of causative factors such as smoking, and pharmacological therapy with combinations of inhaled and/or oral bronchodilators and corticosteroids. Lung transplantation is an established but infrequent option due to donor shortages. The nonevidence-based application of lung volume reduction surgery as palliation for patients with severe emphysema culminated in the US federally approved multicenter National Emphysema Treatment Trial published in 2003. This article reviews recent guidelines concerning chronic obstructive pulmonary disease management as outlined in the 2002 Global Initiative for Obstructive Lung Disease Workshop Report, focuses on published data regarding the cost-effectiveness of lung volume reduction surgery and outlines some less invasive techniques that are on the horizon.

Keywords: bronchoscopic lung volume reduction; cost-effectiveness; cost-of-illness; chronic obstructive pulmonary disease; Global Initiative for Obstructive Lung Disease; lung volume reduction surgery economics; National Emphysema Treatment Trial

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14737167.3.6.729

Publication date: 2003-12-01

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• Expert Review of Pharmacoeconomics & Outcomes Research provides expert commentary on cost-benefit and pharmacoeconomic issues relating to the clinical use of drugs and therapeutic approaches. Coverage includes pharmacoeconomics and quality-of-life research, therapeutic outcomes, evidence-based medicine and cost-benefit research.
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