Authors: Sintonen, Harri; Johansson, Stiina; Ohinmaa, Arto; Apajasalo, Marjo; Kainulainen, Petri; Heikkinen, Jorma

Source: Expert Review of Pharmacoeconomics and Outcomes Research, Volume 3, Number 3, June 2003 , pp. 351-361(11)

Publisher: Expert Reviews

Abstract:

Hormone replacement therapy has been shown to effectively relieve postmenopausal symptoms. However, its impact on health-related quality of life is not well documented. There is no gold standard instrument available for measuring the effects of hormone replacement therapy on health-related quality of life of postmenopausal women. Furthermore, no systematic comparison of health-related quality of life measures has been undertaken within the field. An overview of the health-related quality of life measures and scales used in publications on hormone replacement therapy are reviewed. In addition, an analysis to compare the performance of two generic health-related quality of life measures, the Nottingham Health Profile and the 15D are conducted. Both measures performed well in postmenopausal women. However, only preference-based measures, such as 15D, can be used in cost-utility analyses.

Keywords: estradiol valerate plus; medroxyprogesterone acetate; hormone replacement therapy; quality of life; quality of life measures; 15D; Nottingham Health Profile (NHP)

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14737167.3.3.351

Publication date: 2003-06-01

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• Expert Review of Pharmacoeconomics & Outcomes Research provides expert commentary on cost-benefit and pharmacoeconomic issues relating to the clinical use of drugs and therapeutic approaches. Coverage includes pharmacoeconomics and quality-of-life research, therapeutic outcomes, evidence-based medicine and cost-benefit research.
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