Anesthetic drugs and bariatric surgery

Authors: Lemmens, Hendrikus JM; Brodsky, Jay B

Source: Expert Review of Neurotherapeutics, Volume 6, Number 7, July 2006 , pp. 1107-1113(7)

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Abstract:

The prevalence of obesity is increasing worldwide. For severely obese patients, bariatric surgery is the only effective option for sustained weight loss and associated health improvement. As a consequence, the number of bariatric surgical procedures being performed is growing exponentially. Systematic knowledge regarding the effect of obesity on the pharmacokinetics and pharmacodynamics of anesthetic agents is generally lacking, and data for morbidly obese (body mass index [BMI] 40-49 kg/m²)) and super-obese patients (BMI > 50 kg/m²) are almost completely non-existent. Most drug-dosing guidelines are based on results from relatively small studies in moderately obese patients. Future systematic pharmacological research is needed for improved and more rational peri-operative care of morbidly obese patients.

Keywords: body mass index; dosage; ideal body weight; lean body weight; morbid obesity; obesity; pharmacodynamics; pharmacokinetics

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14737175.6.7.1107

Publication date: 2006-07-01

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Expert Review of Neurotherapeutics provides expert commentary on the use of drugs and medicines in clinical neurology and neuropsychiatry. Coverage includes disease management, new medicines and drugs in neurology, therapeutic indications, diagnostics, medical treatment guidelines and neurological diseases such as stroke, epilepsy, Alzheimer's and Parkinson's.
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