Adverse effects in the treatment of Parkinson’s disease

Author: Singer, Carlos

Source: Expert Review of Neurotherapeutics, Volume 2, Number 1, January 2002 , pp. 105-118(14)

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Abstract:

Side effects to antiparkinsonian drugs constitute an important component of the daily management of patients with Parkinson’s disease. Treatment with levodopa frequently leads to motor fluctuations and dyskinesias. Hallucinosis, nausea and vomiting, drowsiness, orthostatic hypotension and peripheral edema can be managed by dose reduction, medication substitution and specific counteractive measures. Anticholinergics frequently cause cognitive or autonomic symptoms while ergot-derived dopamine agonists carry unique, albeit rare, risks of fibrotic, vasoconstrictive and dermatological side effects. Current areas of controversy include: dopamine agonist-induced sleep attacks, increased mortality with the combination of selegiline and levodopa and the association of levodopa with melanoma.

Keywords: anticholinergics; COMT inhibitors; dopamine agonists; malignant melonoma; MAO-B inhibitors; Parkinson’s disease; side effects

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14737175.2.1.105

Publication date: 2002-01-01

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Expert Review of Neurotherapeutics provides expert commentary on the use of drugs and medicines in clinical neurology and neuropsychiatry. Coverage includes disease management, new medicines and drugs in neurology, therapeutic indications, diagnostics, medical treatment guidelines and neurological diseases such as stroke, epilepsy, Alzheimer's and Parkinson's.
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