Authors: Muise, Aleixo; Rotin, Daniela

Source: Expert Review of Molecular Diagnostics, Volume 8, Number 4, July 2008 , pp. 465-477(13)

Publisher: Expert Reviews

Abstract:

Inflammatory bowel disease is a complex multifactorial disease with a strong genetic component. Recent studies have identified innate immunity (NOD2), autophagy (ATG16L1) and Th17 pathway (IL23R) genes in the pathogenesis of Crohn's disease. The pathogenesis of ulcerative colitis (UC) is less clear; however, there is growing evidence that proteins involved in the apical junction complex are involved in UC. Here we review the up-to-date studies on the genetic basis for IBD and explore the newly described UC-associated apical junction complex pointing to a primary defect in barrier defense. We will focus on the PTPRS (encoding PTPσ) gene and discuss its and other apical junction complex proteins' role in the pathogenesis of UC.

Keywords: adherens junction; apical junction complex; Crohn's disease; inflammatory bowel disease; protein tyrosine phosphatase; PTPσ; PTPRS; ulcerative colitis

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14737159.8.4.465

Affiliations: 1: †1Division of Gastroenterology, Hepatology & Nutrition, Department of Pediatrics, Program in Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada., Email: aleixo.muise@sickkids.ca

Publication date: 2008-07-01

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• Expert Review of Molecular Diagnostics provides expert reviews on molecular diagnostic technologies and applied pharmacogenomics in clinical medicine. Coverage includes molecular diagnostics, biomarkers, diagnostic technologies, microarrays and biochips, proteomics, pharmacogenomics, pharmacogenetics and personalized medicine.
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