Authors: Krishna, C Murali; Kurien, Jacob; Mathew, Stanley; Rao, Lakshmi; Maheedhar, K; Kumar, K Kalyan; Chowdary, MVP

Source: Expert Review of Molecular Diagnostics, Volume 8, Number 2, March 2008 , pp. 149-166(18)

Publisher: Expert Reviews

Abstract:

Breast cancer is one of the leading female cancers. The major drawback of the gold standard of screening, mammography, is the high rate of false reports, aside from the risk from repeated exposure to harmful ionizing radiations. Histopathology, the gold standard of diagnosis, is time consuming and often prone to subjective interpretations. Molecular level diagnosis omics is becoming increasingly popular; among these is metabolomics, diagnosis based on metabolic fingerprinting. In the present article we review a Raman spectroscopic approach to metabolic fingerprinting in breast cancer detection. This review opens with a brief background on anatomical and etiological aspects of breast cancers. We present an overview of conventional detection approaches in breast cancer screening and diagnosis methods, followed by a concise note on the basics of optical spectroscopy and its applications in the screening/diagnosis of breast malignancy. We present the recent developments in Raman spectroscopic diagnosis of breast cancers and also share our experience in Raman spectroscopic classification of normal, benign and malignant breast tissues. Perspectives and current status of Raman spectroscopic screening/diagnosis of breast cancers are also discussed.

Keywords: histopathology; limit test; mammography; optical diagnosis; optical pathology; optical spectroscopy; PCA

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14737159.8.2.149

Affiliations: 1: Scientific Officer E and Principal Investigator, Chilakapati Laboratory, ACTREC, TMC, Kharghar, Sector 22, Navi Mumbai 410208, India; Former affiliation: Center for Laser Spectroscopy, Manipal Life Science Center, Manipal University, Manipal, Ind

Publication date: 2008-03-01

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• Expert Review of Molecular Diagnostics provides expert reviews on molecular diagnostic technologies and applied pharmacogenomics in clinical medicine. Coverage includes molecular diagnostics, biomarkers, diagnostic technologies, microarrays and biochips, proteomics, pharmacogenomics, pharmacogenetics and personalized medicine.
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