Home >> Expert Review of Molecular Diagnostics, Volume 8, Number 1

1,5-anhydroglucitol (GlycoMark™) as a marker of short-term glycemic control and glycemic excursions

Author: Dungan, Kathleen M

Source: Expert Review of Molecular Diagnostics, Volume 8, Number 1, January 2008 , pp. 9-19(11)

Publisher: Expert Reviews

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Abstract:

1,5-anhydroglucitol (1,5-AG) is a validated marker of short-term glycemic control. It is a metabolically inert polyol that competes with glucose for reabsorption in the kidneys. Otherwise stable levels of 1,5-AG are rapidly depleted as blood glucose levels exceed the renal threshold for glucosuria. 1,5-AG more accurately predicts rapid changes in glycemia than hemoglobin A1C (A1C) or fructosamine. It is also more tightly associated with glucose fluctuations and postprandial glucose. Thus, 1,5-AG may offer complementary information to A1C. This review will summarize the limitations of current methods of assessing glycemic control, assess the data to support 1,5-AG as a glycemic marker and highlight the scenarios by which 1,5-AG may fill the gap in assessing glycemic control.

Keywords: 1,5-anhydroglucitol; A1C; glucose; glycemic control; glycemic excursion; glycemic variability; post-prandial glucose

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14737159.8.1.9

Affiliations: 1: Ohio State University, 4th Floor McCampbell Hall, 1581 Dodd Drive, Columbus, OH 43210, USA., Email: kathleen.dungan@osumc.edu

Publication date: 2008-01-01

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