Potential role of body fluid ¹H NMR metabonomics as a prognostic and diagnostic tool

Author: Ala-Korpela, Mika

Source: Expert Review of Molecular Diagnostics, Volume 7, Number 6, November 2007 , pp. 761-773(13)

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Abstract:

This review briefly handles the use of ¹H NMR spectroscopy in lipoprotein subclass analytics. Potential diagnostic uses of ¹H NMR metabonomics of human serum for coronary heart disease, diabetic nephropathy and cancer are also discussed. In addition, miscellaneous recent applications of NMR metabonomics (e.g., a pharmacometabonomic tactic to personalize drug treatment) as well as multi-organ, multispecies and multi-omics approaches to molecular systems biology are featured. Some related experimental and data analysis methodologies are briefly introduced with respect to the biochemical rationales. Critical considerations on the potential diagnostic value of in vitro ¹H NMR are presented together with optimism toward the usage of body fluid ¹H NMR metabonomics in disease risk assessment and as an aid for personalized medicine.

Keywords: body fluid; cancer; coronary heart disease; diabetes; diagnostics; lipoprotein subclasses; metabolomics/metabonomics; NMR spectroscopy; personalized medicine; risk assessment

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14737159.7.6.761

Publication date: 2007-11-01

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Expert Review of Molecular Diagnostics provides expert reviews on molecular diagnostic technologies and applied pharmacogenomics in clinical medicine. Coverage includes molecular diagnostics, biomarkers, diagnostic technologies, microarrays and biochips, proteomics, pharmacogenomics, pharmacogenetics and personalized medicine.
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