Modeling inflammatory bowel disease: the zebrafish as a way forward

Authors: Love, Donald R; Lan, Chuan-Ching; Dodd, Andrew; Shelling, Andrew N; McNabb, Warren C; Ferguson, Lynnette R

Source: Expert Review of Molecular Diagnostics, Volume 7, Number 2, March 2007 , pp. 177-193(17)

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Abstract:

The zebrafish has proved to be an informative model of vertebrate development and, more recently, an emerging model of human disease. The realization of the full potential of the zebrafish as a disease model lies in two interdependent areas. The first is an appreciation that the often overlooked strength of this species lies in allowing the design of experiments that address the interplay of genetics and the environment in a manipulable manner. The second is in the application and further development of gene targeting approaches. These twin features will be addressed in this review in the context of modeling inflammatory bowel disease.

Keywords: disease modeling; gene regulation; gene-environment interaction; inflammatory bowel disease; microflora; real-time imaging; small interfering RNA; zebrafish

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14737159.7.2.177

Publication date: 2007-03-01

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Expert Review of Molecular Diagnostics provides expert reviews on molecular diagnostic technologies and applied pharmacogenomics in clinical medicine. Coverage includes molecular diagnostics, biomarkers, diagnostic technologies, microarrays and biochips, proteomics, pharmacogenomics, pharmacogenetics and personalized medicine.
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