Clinical assessment of assays for diagnosis of herpes simplex infection

Authors: Ryan, Claire; Kinghorn, George

Source: Expert Review of Molecular Diagnostics, Volume 6, Number 5, September 2006 , pp. 767-775(9)

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Abstract:

It is becoming increasingly clear that the herpes simplex viruses (HSVs) 1 and 2 constitute a major, global, public health problem, particularly as genital herpes is implicated in the causation of a significant percentage of onwards transmission of the HIV virus. A major factor in the transmission of HSV is that most carriers are unaware of their diagnosis. In the last few years, the development of nucleic acid amplification technology and type-specific antibody serology to test for HSV-1 and -2 has contributed significantly to the accurate diagnosis of these infections. Despite guidance to the contrary, there is still much use of less sensitive tests such as viral culture and antibody testing based on crude antigen. It is essential that we use the most sensitive and specific diagnostic tests if we are to curb this epidemic.

Keywords: genital herpes; Herpes simplex viruses; HSV; nucleic acid amplification test; PCR; polymerase chain reaction; type-specific serology

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14737159.6.5.767

Publication date: 2006-09-01

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Expert Review of Molecular Diagnostics provides expert reviews on molecular diagnostic technologies and applied pharmacogenomics in clinical medicine. Coverage includes molecular diagnostics, biomarkers, diagnostic technologies, microarrays and biochips, proteomics, pharmacogenomics, pharmacogenetics and personalized medicine.
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