Authors: Gogoi, Radhika; Srinivasan, Shankar; Fishman, David A

Source: Expert Review of Molecular Diagnostics, Volume 6, Number 4, July 2006 , pp. 627-637(11)

Publisher: Expert Reviews

Abstract:

Ovarian cancer accounts for more deaths than all other gynecological malignancies combined, primarily due to advanced stage at initial presentation and our continued inability to detect early-stage disease. Multiple approaches have led to the development of new diagnostic markers for early detection, with no real success (high false positives and poor positive predictive values). Considering the rarity of this disease, the impact of poor diagnostic markers will only be detrimental to the entire early-detection process. Recent advances in proteomics, as well as breakthroughs in analytical techniques and bioinformatics, have enabled researchers to look outside the box, for a panel of proteins (protein profiles) rather than just one or two proteins, thus increasing sensitivity and specificity. This review describes current strategies in the early detection of ovarian cancer, existing markers, their clinical utilities and shortcomings, and highlights newer markers and technologies that are being pursued to improve women's healthcare.

Keywords: diagnostic marker; early detection; epithelial ovarian carcinoma; proteomics

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14737159.6.4.627

Publication date: 2006-07-01

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• Expert Review of Molecular Diagnostics provides expert reviews on molecular diagnostic technologies and applied pharmacogenomics in clinical medicine. Coverage includes molecular diagnostics, biomarkers, diagnostic technologies, microarrays and biochips, proteomics, pharmacogenomics, pharmacogenetics and personalized medicine.
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