Application of genomics and proteomics in Type 1 diabetes pathogenesis research

Authors: Sparre, Thomas; Bergholdt, Regine; Nerup, Jøørn; Pociot, Flemming

Source: Expert Review of Molecular Diagnostics, Volume 3, Number 6, November 2003 , pp. 743-757(15)

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Abstract:

Type 1 diabetes is a polygenic, multifactorial autoimmune disease characterized by selective and irreversible destruction of the insulin-producing ββ-cells in the pancreatic islets of Langerhans. An exogenous supply of insulin is required to sustain life after the onset of Type 1 diabetes. Despite decades of intensive research into its pathogenesis, no single gene or protein has been found to be responsible for Type 1 diabetes. This review will describe the use of large-scale genomics and proteomics in studying the pathogenesis of Type 1 diabetes, and will discuss future directions of research in the field.

Keywords: 2D gel electrophoresis; genome scan; genomics; insulin-dependent diabetes mellitus; pathogenesis; protein expression profile; proteome analysis; proteomics; transcriptomics; Type 1 diabetes

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14737159.3.6.743

Publication date: 2003-11-01

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Expert Review of Molecular Diagnostics provides expert reviews on molecular diagnostic technologies and applied pharmacogenomics in clinical medicine. Coverage includes molecular diagnostics, biomarkers, diagnostic technologies, microarrays and biochips, proteomics, pharmacogenomics, pharmacogenetics and personalized medicine.
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