The CASTLE study: atazanavir/r versus lopinavir/r in antiretroviral-naive patients

Author: Chetchotisakd, Ploenchan

Source: Expert Review of Anti-Infective Therapy, Volume 7, Number 7, September 2009 , pp. 801-805(5)

Buy & download fulltext article:

Price: $73.00 plus tax (Refund Policy)

Abstract:

With the introduction of combination antiretroviral therapy (cART), there have been dramatic reductions in mortality and morbidity of HIV-1-infected patients. Protease inhibitor-based regimens remain a cornerstone of cART owing to their potency and high genetic barrier to resistance. The comparison of atazanavir/ritonavir in naive subjects in combination with tenofovir-emtricitabine versus lopinavir/ritonavir in combination with tenofovir-emtricitabine to assess safety and efficacy (CASTLE) study is a noninferiority trial in which the efficacy, safety and tolerability of atazanavir-ritonavir and lopinavir-ritonavir were compared in antiretroviral therapy-naive patients. The aim of this paper is to review the CASTLE study and the role of atazanavir-ritonavir as an initial treatment in HIV-1-infected patients.

Keywords: antiretroviral therapy-naive patients; atazanavir-ritonavir; lopinavir-ritonavir

Document Type: Research article

DOI: http://dx.doi.org/10.1586/eri.09.66

Affiliations: 1: Professor of Medicine Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand., Email: ploencha@kku.ac.th

Publication date: 2009-09-01

More about this publication?

Expert Review of Anti-infective Therapy provides expert reviews on therapeutics and diagnostics in the treatment of infectious disease. Coverage includes antibiotics, drug resistance, drug therapy, infectious disease medicine, antibacterial, antimicrobial, antifungal and antiviral approaches, and diagnostic tests.
Editorial Board
Information for Authors
Submit a Paper
Subscribe to this Title
Information for Advertisers
Terms & Conditions
Information for Librarians
Free Trials
ingentaconnect is not responsible for the content or availability of external websites