Tularemia: current diagnosis and treatment options

Authors: Hepburn, Matthew J; Simpson, Andrew JH

Source: Expert Review of Anti-Infective Therapy, Volume 6, Number 2, April 2008 , pp. 231-240(10)

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Abstract:

Tularemia is an infection caused by Francisella tularensis with a worldwide distribution and diverse clinical manifestations. Limitations in both culture and serologic testing have led to substantial research into new diagnostic techniques and their clinical application, with PCR testing as the best example. This review focuses on the utility of culture, PCR and serologic testing for tularemia. In addition, we also review the evidence to support different therapeutic options for tularemia, highlighting both the most effective supporting evidence for therapeutic recommendations as well as gaps in current knowledge. We conclude the article with suggestions regarding potential areas for future research.

Keywords: antibiotics; diagnosis; Francisella tularensis; PCR; treatment; tularemia

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14787210.6.2.231

Affiliations: 1: Major, Medical Corps, United States Army, Exchange Officer, Defence Science and Technology Laboratory, Porton Down, UK., Email: matthew.hepburn@amedd.army.mil

Publication date: 2008-04-01

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Expert Review of Anti-infective Therapy provides expert reviews on therapeutics and diagnostics in the treatment of infectious disease. Coverage includes antibiotics, drug resistance, drug therapy, infectious disease medicine, antibacterial, antimicrobial, antifungal and antiviral approaches, and diagnostic tests.
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