The Dose Verification System (DVS^®) for cancer patients receiving radiation therapy

Authors: Scarantino, Charles W; Beyer, Gloria P

Source: Expert Review of Medical Devices, Volume 5, Number 6, November 2008 , pp. 679-685(7)

Buy & download fulltext article:

Price: $73.00 plus tax (Refund Policy)

Abstract:

The Dose Verification System (DVS^®) is the first implantable radiation dosimeter designed for in situ measurement of dose delivered to the tissue being irradiated. The success of radiation therapy is predicated on maximizing tumor cell death and minimizing normal tissue toxicity. Tumor control increases with the delivery of appropriate radiation doses to the target area. These doses have been determined from in vitro and animal studies, which generated specific dose-response data. However, there has not been a practical system available to ensure that the appropriate dose was being delivered in situ to monitor the daily patient dose during radiation therapy. Studies have shown that dose variations can occur. Recently completed pivotal clinical studies using the DVS found a greater than 7% (positive or negative) change in cumulative dose in seven out of 36 (19%) breast cancer patients; and six out of 29 (21%) and eight out of 19 (42%) patients during large-field and boost irradiation of the prostate. The device is an important step to enable physicians to expand the concept of individualization of therapy.

Keywords: image-guided radiation therapy; implantable dosimeter; individualization of therapy; in situ dosimetry; intensity-modulated radiation therapy

Document Type: Research article

DOI: http://dx.doi.org/10.1586/17434440.5.6.679

Affiliations: 1: Department of Radiation Oncology, Rex Cancer Center, 4420 Lake Boone Trail, Raleigh, NC 27607, USA and, Medical Director, Sicel Technologies, Inc., 380 Gateway Center Boulevard, Suite 308, Morrisville, NC 27560, USA. ; cscarantino@siceltech.com,

Publication date: 2008-11-01

More about this publication?

Expert Review of Medical Devices provides commentary, analysis and debate for all professionals involved in research, development, testing and clinical use of devices.
Editorial Board
Information for Authors
Submit a Paper
Subscribe to this Title
Information for Advertisers
Terms & Conditions
Information for Librarians
Free Trials
ingentaconnect is not responsible for the content or availability of external websites