Cellular magnetic resonance imaging: current status and future prospects

Authors: Arbab, Ali S; Liu, Wei; Frank, Joseph A

Source: Expert Review of Medical Devices, Volume 3, Number 4, July 2006 , pp. 427-439(13)

Buy & download fulltext article:

Price: $73.00 plus tax (Refund Policy)

Abstract:

Cellular magnetic resonance imaging (CMRI) allows for the tracking of the temporal and spatial migration of cells labeled with MR contrast agents within organs and tissues. This rapidly growing area of experimental research has the potential of translating from bench to bedside and may be used in conjunction with cellular therapy clinical trials or in the evaluation of novel drug therapies. Ex vivo labeling of nonphagocytic cells with superparamagnetic iron oxide nanoparticles or paramagnetic contrast agents (i.e., gadolinium or manganese) allows for the detection of single cells or clusters of labeled cells within target tissues using CMRI following either direct implantation or intravenous injection. However, prior to the translation of experimental cell labeling studies to clinical trials, it is essential to perform preclinical evaluation to demonstrate a lack of toxicity, the ability to scale-up labeling using good manufacturing practice and the ability to detect cells by in vivo MRI in relevant model systems.

Keywords: cell tracking; cellular MRI; gene delivery; SPIO; stem cells

Document Type: Research article

DOI: http://dx.doi.org/10.1586/17434440.3.4.427

Publication date: 2006-07-01

More about this publication?

Expert Review of Medical Devices provides commentary, analysis and debate for all professionals involved in research, development, testing and clinical use of devices.
Editorial Board
Information for Authors
Submit a Paper
Subscribe to this Title
Information for Advertisers
Terms & Conditions
Information for Librarians
Free Trials
ingentaconnect is not responsible for the content or availability of external websites