Authors: Engström, Annemarie E; Piek, Jan J; Henriques, José PS

Source: Expert Review of Cardiovascular Therapy, Volume 8, Number 9, September 2010 , pp. 1247-1255(9)

Publisher: Expert Reviews

Abstract:

Although coronary artery bypass grafting remains an important therapeutic option for patients with complex coronary artery disease, percutaneous coronary intervention strategies have become an established alternative. Nevertheless, treatment options for surgery-ineligible patients with complex coronary artery disease used to be limited, especially in patients with a reduced left ventricular function. Those patients are at high risk of profound hypotension and mortality, which may be adequately prevented by prophylactic placement of a percutaneous mechanical assist device. Although many devices have been developed and randomized evidence is still pending, the Impella LP2.5 device (Abiomed-Impella CardioSystems GmbH, Aachen, Germany) seems to be promising as it is easily applicable, carries a low complication rate and provides adequate circulatory support.

Keywords: coronary artery disease; elective percutaneous revascularization; mechanical circulatory support; reduced left ventricular function

Document Type: Research article

DOI: http://dx.doi.org/10.1586/erc.10.93

Affiliations: 1: 1Department of Cardiology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

Publication date: 2010-09-01

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• Expert Review of Cardiovascular Therapy provides expert commentary on the clinical applications of the new medicines, therapeutic agents and diagnostics in cardiovascular disease. Coverage inculdes drug therapy, heart disease, vascular disorders, hypertension, cholesterol in cardiovascular disease, heart disease, stroke, heart failure and cardiovascular surgery.
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