Pathophysiology of coronary artery disease: the case for multiparametric imaging

Authors: Gamble, James HP; Scott, Gemma; Ormerod, Julian OM; Frenneaux, Michael P

Source: Expert Review of Cardiovascular Therapy, Volume 7, Number 3, March 2009 , pp. 299-310(12)

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Abstract:

Interventions to treat coronary artery disease are available but they must be targeted at the correct individuals (and indeed lesions), in order to gain maximal benefit with the minimal adverse effects. Coronary contrast angiography is not able to provide all the information required for the assessment of the effects of artery disease. Other imaging modalities are of growing importance as they can reduce radiation exposure and invasiveness of screening, as well as providing important extra information. The ideal `multiparametric' imaging technique would assess anatomy, viability and lesion activity in a single quick scan. Currently, MRI is the technology closest to achieving this ideal, although the existing technology still has some limitations. This review discusses the currently available techniques for the imaging of coronary anatomy and of myocardial viability, and considers their benefits and limitations. We also discuss the developing field of imaging molecularly targeted to active coronary lesions. Finally we provide a 5-year view of the current and likely future optimal imaging strategies.

Keywords: computed tomography; coronary artery disease; MRI; multiparametric imaging; positron emission tomography; single-photon emission tomography

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14779072.7.3.299

Affiliations: 1: Speciality Registrar, Department of Medicine, Royal Berkshire Hospital, Reading, Berkshire, RG1 5AN, UK., Email: james.gamble@royalberkshire.nhs.uk

Publication date: 2009-03-01

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Expert Review of Cardiovascular Therapy provides expert commentary on the clinical applications of the new medicines, therapeutic agents and diagnostics in cardiovascular disease. Coverage inculdes drug therapy, heart disease, vascular disorders, hypertension, cholesterol in cardiovascular disease, heart disease, stroke, heart failure and cardiovascular surgery.
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Pathophysiology of coronary artery disease: the case for multiparametric imaging

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