Add-on manidipine versus amlodipine in diabetic patients with hypertension and microalbuminuria: the AMANDHA study
Authors: Martinez-Martin, Francisco Javier1; Saiz-Satjes, Margarita
Source: Expert Review of Cardiovascular Therapy, Volume 6, Number 10, November 2008 , pp. 1347-1355(9)
Publisher: Expert Reviews
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Abstract:
The aim of this study was to compare the efficacy and safety of adding manidipine 20 mg versus amlodipine 10 mg to the treatment of diabetic patients with uncontrolled hypertension and microalbuminuria despite full-dose treatment with a renin-angiotensin system blocker for at least 6 months. Patients were randomized to receive manidipine (n = 61) or amlodipine (n = 30) in a 2:1 ratio for 6 months and monitored for microalbuminuria for an additional extension phase of 18 months. Manidipine and amlodipine decreased blood pressure values to a similar extent. Urinary albumin excretion was reduced by 65.5% with manidipine versus 20% with amlodipine (p < 0.01) at 6 months and 62.7 versus 16.6% (p < 0.01) at the end of the extension phase. Manidipine was better tolerated than amlodipine. Thus, the addition of manidipine, but not amlodipine, resulted in a large reduction in the urinary albumin excretion rate despite similar blood pressure reductions.Keywords: amlodipine; diabetes; hypertension; manidipine; microalbuminuria
Document Type: Research article
DOI: 10.1586/14779072.6.10.1347
Affiliations: 1: Endocrinology and Nutrition Department, Hospital General de Gran Canaria Dr. Negrin, 35020 Las Palmas de Gran Canaria, Canary Islands, Spain., Email: dr.j.martinez@gmail.com
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