Authors: Martinez-Martin, Francisco Javier; Saiz-Satjes, Margarita

Source: Expert Review of Cardiovascular Therapy, Volume 6, Number 10, November 2008 , pp. 1347-1355(9)

Publisher: Expert Reviews

Abstract:

The aim of this study was to compare the efficacy and safety of adding manidipine 20 mg versus amlodipine 10 mg to the treatment of diabetic patients with uncontrolled hypertension and microalbuminuria despite full-dose treatment with a renin-angiotensin system blocker for at least 6 months. Patients were randomized to receive manidipine (n = 61) or amlodipine (n = 30) in a 2:1 ratio for 6 months and monitored for microalbuminuria for an additional extension phase of 18 months. Manidipine and amlodipine decreased blood pressure values to a similar extent. Urinary albumin excretion was reduced by 65.5% with manidipine versus 20% with amlodipine (p < 0.01) at 6 months and 62.7 versus 16.6% (p < 0.01) at the end of the extension phase. Manidipine was better tolerated than amlodipine. Thus, the addition of manidipine, but not amlodipine, resulted in a large reduction in the urinary albumin excretion rate despite similar blood pressure reductions.

Keywords: amlodipine; diabetes; hypertension; manidipine; microalbuminuria

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14779072.6.10.1347

Affiliations: 1: Endocrinology and Nutrition Department, Hospital General de Gran Canaria Dr. Negrin, 35020 Las Palmas de Gran Canaria, Canary Islands, Spain., Email: dr.j.martinez@gmail.com

Publication date: 2008-11-01

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• Expert Review of Cardiovascular Therapy provides expert commentary on the clinical applications of the new medicines, therapeutic agents and diagnostics in cardiovascular disease. Coverage inculdes drug therapy, heart disease, vascular disorders, hypertension, cholesterol in cardiovascular disease, heart disease, stroke, heart failure and cardiovascular surgery.
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