Home >> Expert Review of Cardiovascular Therapy, Volume 6, Number 8

Role of IGF-1 in glucose regulation and cardiovascular disease

Authors: Abbas, Afroze; Grant, Peter J; Kearney, Mark T

Source: Expert Review of Cardiovascular Therapy, Volume 6, Number 8, September 2008 , pp. 1135-1149(15)

Publisher: Expert Reviews

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Abstract:

IGF-1 is a peptide hormone that is expressed in most tissues. It shares significant structural and functional similarities with insulin, and is implicated in the pathogenesis of insulin resistance and cardiovascular disease. Recombinant human IGF-1 has been used in Type 2 diabetes to improve insulin sensitivity and aid glycemic control. There is evidence supporting IGF-1 as a vascular protective factor and it may also be beneficial in the treatment of chronic heart failure. Further understanding of the effects of IGF-1 signaling in health and disease may lead to novel approaches to the prevention and treatment of diabetes and cardiovascular disease.

Keywords: cardiovascular disease; growth hormone; growth hormone deficiency; heart failure; IGF-1; insulin resistance; Type 2 diabetes

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14779072.6.8.1135

Affiliations: 1: BHF Clinical Research Fellow, Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, LS2 9JT, UK., Email: a.abbas@leeds.ac.uk

Publication date: 2008-09-01

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